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This is a generalized metabolic disease characterized by atrophy or malfunction of the thyroid gland. Clinical symptoms include obesity, lethargy, and/or coat problems. Affected animals may also have various reproductive problems, including irregular or absent estrus (heat cycle), and lack of fertility in both male and female.

Diagnosis of hypothyroidism is by laboratory tests measuring levels of T3 and T4 (produced by the thyroid gland) in the blood. Treatment consists of daily administration of L-thyroxin orally and, when successfully treated, the prognosis is excellent and the dogs life span is normal although the dog may require lifelong thyroid supplementation.

Spinoni with Hypothyroidism should not be used for breeding.